3RAF
Quinazolinedione-DNA cleavage complex of type IV topoisomerase from S. pneumoniae
Summary for 3RAF
Entry DOI | 10.2210/pdb3raf/pdb |
Related | 2NOV 3FOE 3FOF 3K9F 3KSA 3KSB 3LTN 3RAD 3RAE |
Descriptor | DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, 5'-D(*CP*AP*TP*GP*AP*AP*T)-3', ... (9 entities in total) |
Functional Keywords | protein-dna cleavage complex, topoisomerase iia, quinazolinedione pd 0305970, isomerase-dna-antibiotic complex, isomerase/dna/antibiotic |
Biological source | Streptococcus pneumoniae More |
Cellular location | Cell membrane; Peripheral membrane protein (By similarity): P72525 |
Total number of polymer chains | 8 |
Total formula weight | 185503.59 |
Authors | Laponogov, I.,Pan, X.-S.,Veselkov, D.A.,McAuley, K.E.,Fisher, L.M.,Sanderson, M.R. (deposition date: 2011-03-28, release date: 2012-03-28) |
Primary citation | Laponogov, I.,Pan, X.-S.,Veselkov, D.A.,McAuley, K.E.,Fisher, L.M.,Sanderson, M.R. Inhibitor-stabilised cleavage complexes of topoisomerase IIa: structural analysis of drug-dependent inter- and intramolecular interactions To be Published, |
Experimental method | X-RAY DIFFRACTION (3.24 Å) |
Structure validation
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