3R8I

Crystal Structure of PPARgamma with an achiral ureidofibrate derivative (RT86)

Summary for 3R8I

Entry DOI	10.2210/pdb3r8i/pdb
Related	2I4J 2I4P 2I4Z
Descriptor	Peroxisome proliferator-activated receptor gamma, 2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]ethyl}phenoxy)-2-methylpropanoic acid (3 entities in total)
Functional Keywords	protein-dna complex, bundle of alpha-helices, small four-stranded beta-sheet, transcription, activator, diabetes mellitus, obesity, transcription regulation, dna binding, phosphorylation, nucleus
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	65826.21
Authors	Pochetti, G.,Montanari, R.,Loiodice, F.,Laghezza, A.,Fracchiolla, G.,Lavecchia, A.,Novellino, E.,Crestani, M. (deposition date: 2011-03-24, release date: 2012-01-11, Last modification date: 2023-09-13)
Primary citation	Porcelli, L.,Gilardi, F.,Laghezza, A.,Piemontese, L.,Mitro, N.,Azzariti, A.,Altieri, F.,Cervoni, L.,Fracchiolla, G.,Giudici, M.,Guerrini, U.,Lavecchia, A.,Montanari, R.,Di Giovanni, C.,Paradiso, A.,Pochetti, G.,Simone, G.M.,Tortorella, P.,Crestani, M.,Loiodice, F. Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. J.Med.Chem., 55:37-54, 2012 Cited by PubMed: 22081932 DOI: 10.1021/jm201306q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation