3R7O

Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-2461 analog

3R7O の概要

• エントリーDOI: 10.2210/pdb3r7o/pdb
• 分子名称: Hepatocyte growth factor receptor, N-[(2R)-1,4-dioxan-2-ylmethyl]-N-methyl-N'-{5-oxo-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}sulfuric diamide (3 entities in total)
• 機能のキーワード: tyrosine kinase, phosphotyrosine, 1234, 1235, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35678.02

構造登録者

Soisson, S.M.,Rickert, K.,Patel, S.B.,Munshi, S.,Lumb, K.J. (登録日: 2011-03-22, 公開日: 2012-02-01, 最終更新日: 2017-11-08)

• 主引用文献: Rickert, K.W.,Patel, S.B.,Allison, T.J.,Byrne, N.J.,Darke, P.L.,Ford, R.E.,Guerin, D.J.,Hall, D.L.,Kornienko, M.,Lu, J.,Munshi, S.K.,Reid, J.C.,Shipman, J.M.,Stanton, E.F.,Wilson, K.J.,Young, J.R.,Soisson, S.M.,Lumb, K.J.; Structural basis for selective small molecule kinase inhibition of activated c-Met.; J.Biol.Chem., 286:11218-11225, 2011; PubMed: 21247903; DOI: 10.1074/jbc.M110.204404

実験手法

X-RAY DIFFRACTION (2.3 Å)