3R6C

Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS179)

3R6C の概要

• エントリーDOI: 10.2210/pdb3r6c/pdb
• 関連するPDBエントリー: 3QQS 3QR9 3QS8 3QSA
• 分子名称: Anthranilate phosphoribosyltransferase, 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: anthranilate phosphoribosyltransferase, anthranilic acids, magnesium, tryptophan, structural genomics, tb structural genomics consortium, tbsgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 79425.68

構造登録者

Castell, A.,Short, F.L.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (登録日: 2011-03-21, 公開日: 2012-09-26, 最終更新日: 2024-02-21)

• 主引用文献: Castell, A.,Short, F.L.,Evans, G.L.,Cookson, T.V.,Bulloch, E.M.,Joseph, D.D.,Lee, C.E.,Parker, E.J.,Baker, E.N.,Lott, J.S.; The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.; Biochemistry, 52:1776-1787, 2013; PubMed: 23363292; DOI: 10.1021/bi301387m

実験手法

X-RAY DIFFRACTION (1.83 Å)