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3R66

Crystal structure of human ISG15 in complex with NS1 N-terminal region from influenza virus B, Northeast Structural Genomics Consortium Target IDs HX6481, HR2873, and OR2

Summary for 3R66
Entry DOI10.2210/pdb3r66/pdb
Related1XEQ 1Z2M
DescriptorNon-structural protein 1, Ubiquitin-like protein ISG15 (3 entities in total)
Functional Keywordsstructural genomics, psi-biology, northeast structural genomics consortium, nesg, innate immunity, isg15 conjugation, viral protein-antiviral protein complex, viral protein/antiviral protein
Biological sourceInfluenza B virus
More
Cellular locationHost cytoplasm : P03502
Cytoplasm : P05161
Total number of polymer chains4
Total formula weight62471.30
Authors
Guan, R.,Ma, L.C.,Krug, R.M.,Montelione, G.T.,Northeast Structural Genomics Consortium (NESG) (deposition date: 2011-03-21, release date: 2011-06-08, Last modification date: 2023-09-13)
Primary citationGuan, R.,Ma, L.C.,Leonard, P.G.,Brendan, A.R.,Sridharan, H.,Zhao, C.,Krug, R.M.,Montelione, G.T.
The Structure of the complex of ISG15 and Influenza B virus NS1 Protein: implications for the mechanism of SN1-mediated inhibition of ISG15 conjugation
To be Published,
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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