3R54

Human Cyclophilin D Complexed with a Fragment

Summary for 3R54

Entry DOI	10.2210/pdb3r54/pdb
Related	3R49 3R4G 3R56 3R57 3R59 3RCF 3RCG 3RCI 3RCK 3RCL 3RD9 3RDA 3RDB 3RDC 3RDD
Descriptor	Peptidyl-prolyl cis-trans isomerase F, mitochondrial, pyrrolidine-1-carbaldehyde (3 entities in total)
Functional Keywords	beta barrel, prolyl cis/trans isomerase, mitochondria, inhibitor, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion matrix : P30405
Total number of polymer chains	1
Total formula weight	17969.53
Authors	Colliandre, L.,Ahmed-Belkacem, H.,Bessin, Y.,Pawlotsky, J.M.,Guichou, J.F. (deposition date: 2011-03-18, release date: 2012-03-21, Last modification date: 2024-02-21)
Primary citation	Ahmed-Belkacem, A.,Colliandre, L.,Ahnou, N.,Nevers, Q.,Gelin, M.,Bessin, Y.,Brillet, R.,Cala, O.,Douguet, D.,Bourguet, W.,Krimm, I.,Pawlotsky, J.M.,Guichou, J.F. Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nat Commun, 7:12777-12777, 2016 Cited by PubMed: 27652979 DOI: 10.1038/ncomms12777 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation