3R43

AKR1C3 complexed with mefenamic acid

Summary for 3R43

• Entry DOI: 10.2210/pdb3r43/pdb
• Related: 3R58 3R6I
• Descriptor: Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID, ... (5 entities in total)
• Functional Keywords: tim barrel, aldo-keto reductase, nitro reductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P42330
• Total number of polymer chains: 1
• Total formula weight: 39210.33

Authors

Squire, C.J.,Teague, R.M.,Yosaatmadja, L. (deposition date: 2011-03-17, release date: 2012-03-28, Last modification date: 2023-09-13)

• Primary citation: Flanagan, J.U.,Yosaatmadja, Y.,Teague, R.M.,Chai, M.Z.,Turnbull, A.P.,Squire, C.J.; Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.; Plos One, 7:e43965-e43965, 2012; PubMed: 22937138; DOI: 10.1371/journal.pone.0043965

Experimental method

X-RAY DIFFRACTION (2 Å)