3R1N

MK3 kinase bound to Compound 5b

Summary for 3R1N

Entry DOI	10.2210/pdb3r1n/pdb
Related	3R2B 3R2Y 3R30
Descriptor	MAP kinase-activated protein kinase 3, 2'-[2-(1,3-benzodioxol-5-yl)pyrimidin-4-yl]-5',6'-dihydrospiro[piperidine-4,7'-pyrrolo[3,2-c]pyridin]-4'(1'H)-one (3 entities in total)
Functional Keywords	kinase domain with bound inhibitor, kinase domain, phosphotransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus : Q16644
Total number of polymer chains	1
Total formula weight	36832.04
Authors	Oubrie, A.,Kazemier, B. (deposition date: 2011-03-11, release date: 2011-05-25, Last modification date: 2024-02-21)
Primary citation	Barf, T.,Kaptein, A.,Wilde, S.,Heijden, R.,Someren, R.,Demont, D.,Schultz-Fademrecht, C.,Versteegh, J.,Zeeland, M.,Seegers, N.,Kazemier, B.,Kar, B.,Hoek, M.,Roos, J.,Klop, H.,Smeets, R.,Hofstra, C.,Hornberg, J.,Oubrie, A. Structure-based lead identification of ATP-competitive MK2 inhibitors. Bioorg.Med.Chem.Lett., 21:3818-3822, 2011 Cited by PubMed: 21565500 DOI: 10.1016/j.bmcl.2011.04.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09 Å)

Structure validation