3R1A

Closed crystal structure of cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene

Summary for 3R1A

• Entry DOI: 10.2210/pdb3r1a/pdb
• Related: 3R1B
• Descriptor: Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, (4-tert-butylphenyl)acetaldehyde, ... (4 entities in total)
• Functional Keywords: cytochrome p450 2b4, monooxygenase, oxidoreductase, membrane protein, t302 covalently linked to tert-butylphenylacetylene, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein: P00178
• Total number of polymer chains: 8
• Total formula weight: 439694.59

Authors

Gay, S.C.,Zhang, H.,Stout, C.D.,Hollenberg, P.F.,Halpert, J.R. (deposition date: 2011-03-09, release date: 2011-05-11, Last modification date: 2023-09-13)

• Primary citation: Gay, S.C.,Zhang, H.,Wilderman, P.R.,Roberts, A.G.,Liu, T.,Li, S.,Lin, H.L.,Zhang, Q.,Woods, V.L.,Stout, C.D.,Hollenberg, P.F.,Halpert, J.R.; Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity.; Biochemistry, 50:4903-4911, 2011; PubMed: 21510666; DOI: 10.1021/bi200482g

Experimental method

X-RAY DIFFRACTION (3.5 Å)