3R0T

Crystal structure of human protein kinase CK2 alpha subunit in complex with the inhibitor CX-5279

3R0T の概要

• エントリーDOI: 10.2210/pdb3r0t/pdb
• 関連するPDBエントリー: 3PE1 3PE2
• 分子名称: Casein kinase II subunit alpha, 3-(cyclopropylamino)-5-{[3-(trifluoromethyl)phenyl]amino}pyrimido[4,5-c]quinoline-8-carboxylic acid, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: kinase, ck2-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41729.28

構造登録者

Battistutta, R.,Papinutto, E.,Lolli, G.,Pierre, F.,Haddach, M.,Ryckman, D.M. (登録日: 2011-03-09, 公開日: 2011-12-07, 最終更新日: 2023-09-13)

• 主引用文献: Battistutta, R.,Cozza, G.,Pierre, F.,Papinutto, E.,Lolli, G.,Sarno, S.,O'Brien, S.E.,Siddiqui-Jain, A.,Haddach, M.,Anderes, K.,Ryckman, D.M.,Meggio, F.,Pinna, L.A.; Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.; Biochemistry, 50:8478-8488, 2011; PubMed: 21870818; DOI: 10.1021/bi2008382

実験手法

X-RAY DIFFRACTION (1.75 Å)