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3R01

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors

Summary for 3R01
Entry DOI10.2210/pdb3r01/pdb
Related3R00 3R02 3R04
DescriptorProto-oncogene serine/threonine-protein kinase pim-1, IMIDAZOLE, 5-bromo-7-methoxy-1-benzofuran-2-carboxylic acid, ... (4 entities in total)
Functional Keywordskinase, pim1, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationIsoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains1
Total formula weight34890.33
Authors
Liu, J. (deposition date: 2011-03-07, release date: 2011-05-11, Last modification date: 2024-02-21)
Primary citationXiang, Y.,Hirth, B.,Asmussen, G.,Biemann, H.P.,Bishop, K.A.,Good, A.,Fitzgerald, M.,Gladysheva, T.,Jain, A.,Jancsics, K.,Liu, J.,Metz, M.,Papoulis, A.,Skerlj, R.,Stepp, J.D.,Wei, R.R.
The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.
Bioorg.Med.Chem.Lett., 21:3050-3056, 2011
Cited by
PubMed: 21507633
DOI: 10.1016/j.bmcl.2011.03.030
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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