3QXR
Crystal structure of the brominated CKIT-1 proto-oncogene promoter quadruplex DNA
Summary for 3QXR
Entry DOI | 10.2210/pdb3qxr/pdb |
Descriptor | 5'-D(*AP*GP*GP*GP*AP*GP*GP*GP*CP*GP*CP*(BRU)P*GP*GP*GP*AP*GP*GP*AP*GP*GP*G)-3', POTASSIUM ION, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | dna quadruplex, regulation, ckit-1, dna |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 14587.26 |
Authors | Wei, D.,Parkinson, G.N.,Neidle, S. (deposition date: 2011-03-02, release date: 2012-01-18, Last modification date: 2023-09-13) |
Primary citation | Wei, D.,Parkinson, G.N.,Reszka, A.P.,Neidle, S. Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation. Nucleic Acids Res., 40:4691-4700, 2012 Cited by PubMed: 22287624DOI: 10.1093/nar/gks023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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