3QWR

Crystal structure of IL-23 in complex with an adnectin

3QWR の概要

• エントリーDOI: 10.2210/pdb3qwr/pdb
• 関連するPDBエントリー: 3QWQ
• 分子名称: Interleukin-12 subunit beta, Interleukin-23 subunit alpha, ADNECTIN, ... (5 entities in total)
• 機能のキーワード: four-helix bundle cytokine, ig domain, glycoprotein, immunoglobulin domain, secreted, antiviral defense, immune response, inflammatory response, innate immunity, tissue remodeling, adnectin, engineered binding protein, antibody mimic, protein binding-cytokine complex, protein binding/cytokine
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 66664.54

構造登録者

Wei, A.,Sheriff, S. (登録日: 2011-02-28, 公開日: 2012-02-01, 最終更新日: 2023-09-13)

• 主引用文献: Ramamurthy, V.,Krystek, S.R.,Bush, A.,Wei, A.,Emanuel, S.L.,Das Gupta, R.,Janjua, A.,Cheng, L.,Murdock, M.,Abramczyk, B.,Cohen, D.,Lin, Z.,Morin, P.,Davis, J.H.,Dabritz, M.,McLaughlin, D.C.,Russo, K.A.,Chao, G.,Wright, M.C.,Jenny, V.A.,Engle, L.J.,Furfine, E.,Sheriff, S.; Structures of adnectin/protein complexes reveal an expanded binding footprint.; Structure, 20:259-269, 2012; PubMed: 22325775; DOI: 10.1016/j.str.2011.11.016

実験手法

X-RAY DIFFRACTION (3.25 Å)