3QW8
Crystal structure of the protease domain of Botulinum Neurotoxin Serotype A with a peptide inhibitor CRGC
Summary for 3QW8
Entry DOI | 10.2210/pdb3qw8/pdb |
Related | 3BWI 3C88 3C89 3C8A 3C8B 3DDA 3DDB 3QW5 3QW6 3QW7 |
Descriptor | Botulinum neurotoxin type A, inhibitory peptide CRGC, ZINC ION, ... (7 entities in total) |
Functional Keywords | endopeptidase, syntaxin, bio-warfare agent, membrane, metal-binding, metalloprotease, protease, secreted, transmembrane, snap25, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Clostridium botulinum |
Cellular location | Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9 |
Total number of polymer chains | 2 |
Total formula weight | 50290.94 |
Authors | Kumaran, D.,Swaminathan, S. (deposition date: 2011-02-27, release date: 2012-02-08, Last modification date: 2023-09-13) |
Primary citation | Kumar, G.,Kumaran, D.,Ahmed, S.A.,Swaminathan, S. Peptide inhibitors of botulinum neurotoxin serotype A: design, inhibition, cocrystal structures, structure-activity relationship and pharmacophore modeling. Acta Crystallogr.,Sect.D, 68:511-520, 2012 Cited by PubMed: 22525749DOI: 10.1107/S0907444912003551 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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