3QUP
Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)
Summary for 3QUP
| Entry DOI | 10.2210/pdb3qup/pdb |
| Descriptor | Tyrosine-protein kinase receptor TYRO3, (5-fluoro-1H-indol-2-yl)[(3R)-1'-[(3R)-piperidin-3-yl]spiro[indole-3,3'-pyrrolidin]-1(2H)-yl]methanone (3 entities in total) |
| Functional Keywords | protein kinase inhibitor, receptor tyrosine kinase, spirocycle, kinase domain, phosphotransfer, gas6 ligand, cytoplasmic surface, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Mus musculus (mouse) |
| Cellular location | Cell membrane; Single-pass type I membrane protein: P55144 |
| Total number of polymer chains | 1 |
| Total formula weight | 37189.96 |
| Authors | Ohren, J.F. (deposition date: 2011-02-24, release date: 2011-12-21, Last modification date: 2024-02-21) |
| Primary citation | Powell, N.A.,Kohrt, J.T.,Filipski, K.J.,Kaufman, M.,Sheehan, D.,Edmunds, J.E.,Delaney, A.,Wang, Y.,Bourbonais, F.,Lee, D.Y.,Schwende, F.,Sun, F.,McConnell, P.,Catana, C.,Chen, H.,Ohren, J.,Perrin, L.A. Novel and selective spiroindoline-based inhibitors of sky kinase. Bioorg.Med.Chem.Lett., 22:190-193, 2012 Cited by PubMed: 22119469DOI: 10.1016/j.bmcl.2011.11.036 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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