3QUP

Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)

3QUP の概要

• エントリーDOI: 10.2210/pdb3qup/pdb
• 分子名称: Tyrosine-protein kinase receptor TYRO3, (5-fluoro-1H-indol-2-yl)[(3R)-1'-[(3R)-piperidin-3-yl]spiro[indole-3,3'-pyrrolidin]-1(2H)-yl]methanone (3 entities in total)
• 機能のキーワード: protein kinase inhibitor, receptor tyrosine kinase, spirocycle, kinase domain, phosphotransfer, gas6 ligand, cytoplasmic surface, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P55144
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37189.96

構造登録者

Ohren, J.F. (登録日: 2011-02-24, 公開日: 2011-12-21, 最終更新日: 2024-02-21)

• 主引用文献: Powell, N.A.,Kohrt, J.T.,Filipski, K.J.,Kaufman, M.,Sheehan, D.,Edmunds, J.E.,Delaney, A.,Wang, Y.,Bourbonais, F.,Lee, D.Y.,Schwende, F.,Sun, F.,McConnell, P.,Catana, C.,Chen, H.,Ohren, J.,Perrin, L.A.; Novel and selective spiroindoline-based inhibitors of sky kinase.; Bioorg.Med.Chem.Lett., 22:190-193, 2012; PubMed: 22119469; DOI: 10.1016/j.bmcl.2011.11.036

実験手法

X-RAY DIFFRACTION (1.9 Å)