3QTI
c-Met Kinase in Complex with NVP-BVU972
Summary for 3QTI
Entry DOI | 10.2210/pdb3qti/pdb |
Descriptor | Hepatocyte growth factor receptor, 6-{[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | kinase, transerase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P08581 |
Total number of polymer chains | 2 |
Total formula weight | 71651.79 |
Authors | Appleton, B.A. (deposition date: 2011-02-22, release date: 2011-07-06, Last modification date: 2024-02-21) |
Primary citation | Tiedt, R.,Degenkolbe, E.,Furet, P.,Appleton, B.A.,Wagner, S.,Schoepfer, J.,Buck, E.,Ruddy, D.A.,Monahan, J.E.,Jones, M.D.,Blank, J.,Haasen, D.,Drueckes, P.,Wartmann, M.,McCarthy, C.,Sellers, W.R.,Hofmann, F. A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients. Cancer Res., 71:5255-5264, 2011 Cited by PubMed: 21697284DOI: 10.1158/0008-5472.CAN-10-4433 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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