3QTI

c-Met Kinase in Complex with NVP-BVU972

3QTI の概要

• エントリーDOI: 10.2210/pdb3qti/pdb
• 分子名称: Hepatocyte growth factor receptor, 6-{[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: kinase, transerase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P08581
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71651.79

構造登録者

Appleton, B.A. (登録日: 2011-02-22, 公開日: 2011-07-06, 最終更新日: 2024-02-21)

• 主引用文献: Tiedt, R.,Degenkolbe, E.,Furet, P.,Appleton, B.A.,Wagner, S.,Schoepfer, J.,Buck, E.,Ruddy, D.A.,Monahan, J.E.,Jones, M.D.,Blank, J.,Haasen, D.,Drueckes, P.,Wartmann, M.,McCarthy, C.,Sellers, W.R.,Hofmann, F.; A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients.; Cancer Res., 71:5255-5264, 2011; PubMed: 21697284; DOI: 10.1158/0008-5472.CAN-10-4433

実験手法

X-RAY DIFFRACTION (2 Å)