3QTC

Crystal structure of the catalytic domain of MmOmeRS, an O-methyl tyrosyl-tRNA synthetase evolved from Methanosarcina mazei PylRS, complexed with O-methyl tyrosine and AMP-PNP

3QTC の概要

• エントリーDOI: 10.2210/pdb3qtc/pdb
• 分子名称: Pyrrolysyl-tRNA synthetase, MAGNESIUM ION, O-methyl-L-tyrosine, ... (6 entities in total)
• 機能のキーワード: pyrrolysyl-trna synthetase, aminoacyl-trna synthetase, atp binding, o-methyl tyrosine binding, magnesium binding, aminoacylation, esterification, ligase
• 由来する生物種: Methanosarcina mazei (Methanosarcina frisia)
• 細胞内の位置: Cytoplasm (By similarity): Q8PWY1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34555.75

構造登録者

Dellas, N.,Takimoto, J.K.,Noel, J.P.,Wang, L. (登録日: 2011-02-22, 公開日: 2011-05-25, 最終更新日: 2023-12-06)

• 主引用文献: Takimoto, J.K.,Dellas, N.,Noel, J.P.,Wang, L.; Stereochemical Basis for Engineered Pyrrolysyl-tRNA Synthetase and the Efficient in Vivo Incorporation of Structurally Divergent Non-native Amino Acids.; Acs Chem.Biol., 6:733-743, 2011; PubMed: 21545173; DOI: 10.1021/cb200057a

実験手法

X-RAY DIFFRACTION (1.75 Å)