3QSK
5 Histidine Variant of the anti-RNase A VHH in Complex with RNAse A
Summary for 3QSK
Entry DOI | 10.2210/pdb3qsk/pdb |
Related | 1BZQ 2P49 |
Descriptor | Ribonuclease pancreatic, Engineered 5 Histidine anti-RNase A Camelid VHH Antibody Domain Variant (3 entities in total) |
Functional Keywords | antibody, single domain, camelid, vhh, sdab, rnase a, ribonuclease a, ph, sensitivity, switch, dependence, linked, equilibria, equilibrium, protein engineering, combinatorial, histidine, scanning, phage display, dual-function, protein-protein interaction, proton binding, hydrolase-immune system complex, hydrolase/immune system |
Biological source | Camelus dromedarius (Arabian camel) More |
Cellular location | Secreted: P61823 |
Total number of polymer chains | 2 |
Total formula weight | 26815.80 |
Authors | Murtaugh, M.L.,Fanning, S.W.,Sharma, T.M.,Terry, A.M.,Horn, J.R. (deposition date: 2011-02-21, release date: 2011-08-10, Last modification date: 2011-11-30) |
Primary citation | Murtaugh, M.L.,Fanning, S.W.,Sharma, T.M.,Terry, A.M.,Horn, J.R. A combinatorial histidine scanning library approach to engineer highly pH-dependent protein switches. Protein Sci., 20:1619-1631, 2011 Cited by PubMed: 21766385DOI: 10.1002/pro.696 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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