2P49

Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.4A resolution: native mono_1 crystal form

Summary for 2P49

• Entry DOI: 10.2210/pdb2p49/pdb
• Descriptor: Ribonuclease pancreatic, ANTIBODY CAB-RN05, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: camelid single-domain antibody, vhh, cab-rn05, rnase a, paratope, yeast surface display, hydrolase-immune system complex, hydrolase/immune system
• Biological source: Camelus dromedarius (Arabian camel); More
• Cellular location: Secreted: P61823
• Total number of polymer chains: 2
• Total formula weight: 26907.76

Authors

Tereshko, V.,Uysal, S.,Margalef, K.,Koide, A.,Kossiakoff, A.A.,Koide, S. (deposition date: 2007-03-11, release date: 2007-08-28, Last modification date: 2023-08-30)

• Primary citation: Koide, A.,Tereshko, V.,Uysal, S.,Margalef, K.,Kossiakoff, A.A.,Koide, S.; Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope.; J.Mol.Biol., 373:941-953, 2007; PubMed: 17888451; DOI: 10.1016/j.jmb.2007.08.027

Experimental method

X-RAY DIFFRACTION (1.38 Å)