3QSF
The first crystal structure of a human telomeric G-quadruplex DNA bound to a metal-containing ligand (a nickel complex)
Summary for 3QSF
Entry DOI | 10.2210/pdb3qsf/pdb |
Related | 1K8P 1KF1 2HRI 3CCO 3CDM 3CE5 3QSC |
Descriptor | 5'-D(*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*T)-3', POTASSIUM ION, [2,2'-{(4,5-difluorobenzene-1,2-diyl)bis[(nitrilo-kappaN)methylylidene]}bis{5-[2-(piperidin-1-yl)ethoxy]phenolato-kappa O}(2-)]nickel (II), ... (4 entities in total) |
Functional Keywords | parallel, telomere, nickel, drug, dna, metal complex |
Total number of polymer chains | 1 |
Total formula weight | 4554.14 |
Authors | Campbell, N.H.,Abd Karim, N.H.,Parkinson, G.N.,Vilar, R.,Neidle, S. (deposition date: 2011-02-21, release date: 2011-12-07, Last modification date: 2023-09-13) |
Primary citation | Campbell, N.H.,Karim, N.H.,Parkinson, G.N.,Gunaratnam, M.,Petrucci, V.,Todd, A.K.,Vilar, R.,Neidle, S. Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes. J.Med.Chem., 55:209-222, 2012 Cited by PubMed: 22112241DOI: 10.1021/jm201140v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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