3QOA

Crystal structure of a human cytochrome P450 2B6 (Y226H/K262R) in complex with the inhibitor 4-Benzylpyridine.

Summary for 3QOA

Entry DOI	10.2210/pdb3qoa/pdb
Related	3IBD 3QU8
Descriptor	Cytochrome P450 2B6, PROTOPORPHYRIN IX CONTAINING FE, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, ... (5 entities in total)
Functional Keywords	p450, cytochrome p450 2b6, monooxygenase, membrane protein, cyp2b6, endoplasmic reticulum, heme, iron, membrane, metal binding, mircosome, phosphoprotein, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P20813
Total number of polymer chains	1
Total formula weight	56420.86
Authors	Shah, M.B.,Pascual, J.,Stout, C.D.,Halpert, J.R. (deposition date: 2011-02-09, release date: 2011-09-14, Last modification date: 2023-09-13)
Primary citation	Shah, M.B.,Pascual, J.,Zhang, Q.,Stout, C.D.,Halpert, J.R. Structures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side Chains. Mol.Pharmacol., 80:1047-1055, 2011 Cited by PubMed: 21875942 DOI: 10.1124/mol.111.074427 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation