3QOA
Crystal structure of a human cytochrome P450 2B6 (Y226H/K262R) in complex with the inhibitor 4-Benzylpyridine.
Summary for 3QOA
Entry DOI | 10.2210/pdb3qoa/pdb |
Related | 3IBD 3QU8 |
Descriptor | Cytochrome P450 2B6, PROTOPORPHYRIN IX CONTAINING FE, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, ... (5 entities in total) |
Functional Keywords | p450, cytochrome p450 2b6, monooxygenase, membrane protein, cyp2b6, endoplasmic reticulum, heme, iron, membrane, metal binding, mircosome, phosphoprotein, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P20813 |
Total number of polymer chains | 1 |
Total formula weight | 56420.86 |
Authors | Shah, M.B.,Pascual, J.,Stout, C.D.,Halpert, J.R. (deposition date: 2011-02-09, release date: 2011-09-14, Last modification date: 2023-09-13) |
Primary citation | Shah, M.B.,Pascual, J.,Zhang, Q.,Stout, C.D.,Halpert, J.R. Structures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side Chains. Mol.Pharmacol., 80:1047-1055, 2011 Cited by PubMed: 21875942DOI: 10.1124/mol.111.074427 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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