3QO9
Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with TSAO-T, a non-nucleoside RT inhibitor (NNRTI)
3QO9 の概要
エントリーDOI | 10.2210/pdb3qo9/pdb |
関連するPDBエントリー | 2ZD1 3DLK |
分子名称 | Reverse transcriptase/ ribonuclease H, p51 RT, 1-[(5R,6R,8R,9R)-4-amino-9-{[tert-butyl(dimethyl)silyl]oxy}-6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4(1H,3H)-dione, ... (4 entities in total) |
機能のキーワード | aids, hiv, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, nonnucleoside, nnrti, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
由来する生物種 | Human immunodeficiency virus type 1 BH10 (HIV-1) 詳細 |
細胞内の位置 | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 114674.69 |
構造登録者 | |
主引用文献 | Das, K.,Bauman, J.D.,Rim, A.S.,Dharia, C.,Clark, A.D.,Camarasa, M.J.,Balzarini, J.,Arnold, E. Crystal Structure of tert-Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding Pocket. J.Med.Chem., 54:2727-2737, 2011 Cited by PubMed: 21446702DOI: 10.1021/jm101536x 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.6 Å) |
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