3QNT

NPC1L1 (NTD) Structure

Summary for 3QNT

Entry DOI	10.2210/pdb3qnt/pdb
Descriptor	Niemann-Pick C1-like protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
Functional Keywords	cholesterol transport protein, transport protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	28517.10
Authors	Kwon, H.J. (deposition date: 2011-02-09, release date: 2011-05-11, Last modification date: 2024-11-06)
Primary citation	Kwon, H.J.,Palnitkar, M.,Deisenhofer, J. The Structure of the NPC1L1 N-Terminal Domain in a Closed Conformation. Plos One, 6:e18722-e18722, 2011 Cited by PubMed Abstract: NPC1L1 is the molecular target of the cholesterol lowering drug Ezetimibe and mediates the intestinal absorption of cholesterol. Inhibition or deletion of NPC1L1 reduces intestinal cholesterol absorption, resulting in reduction of plasma cholesterol levels. PubMed: 21525977 DOI: 10.1371/journal.pone.0018722 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.83 Å)

Structure validation