3QM4

Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex

Summary for 3QM4

• Entry DOI: 10.2210/pdb3qm4/pdb
• Related: 2f9q
• Descriptor: Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, Prinomastat, ... (5 entities in total)
• Functional Keywords: cyp2d6, p450 2d6, p450, monooxygenase, prinomastat, heme, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein: P10635
• Total number of polymer chains: 2
• Total formula weight: 109599.81

Authors

Wang, A.,Stout, C.D.,Johnson, E.F. (deposition date: 2011-02-03, release date: 2012-02-15, Last modification date: 2023-09-13)

• Primary citation: Wang, A.,Savas, U.,Hsu, M.H.,Stout, C.D.,Johnson, E.F.; Crystal Structure of Human Cytochrome P450 2D6 with Prinomastat Bound.; J.Biol.Chem., 287:10834-10843, 2012; PubMed: 22308038; DOI: 10.1074/jbc.M111.307918

Experimental method

X-RAY DIFFRACTION (2.85 Å)