3QI5
Crystal structure of human alkyladenine DNA glycosylase in complex with 3,N4-ethenocystosine containing duplex DNA
Summary for 3QI5
Entry DOI | 10.2210/pdb3qi5/pdb |
Descriptor | DNA-3-methyladenine glycosylase, DNA (5'-D(*GP*AP*CP*AP*TP*GP*(EDC)P*TP*TP*GP*CP*CP*T)-3'), DNA (5'-D(*GP*GP*CP*AP*AP*GP*CP*AP*TP*GP*TP*CP*A)-3'), ... (5 entities in total) |
Functional Keywords | alkyladenine dna glycosylase fold, aag, excision, dna repair, dna binding, nucleus, hydrolase-dna complex, hydrolase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (Potential): P29372 |
Total number of polymer chains | 6 |
Total formula weight | 64674.09 |
Authors | Lingaraju, G.M.,Davis, C.A.,Setser, J.W.,Samson, L.D.,Drennan, C.L. (deposition date: 2011-01-26, release date: 2011-03-09, Last modification date: 2023-09-13) |
Primary citation | Lingaraju, G.M.,Davis, C.A.,Setser, J.W.,Samson, L.D.,Drennan, C.L. Structural Basis for the Inhibition of Human Alkyladenine DNA Glycosylase (AAG) by 3,N4-Ethenocytosine-containing DNA. J.Biol.Chem., 286:13205-13213, 2011 Cited by PubMed: 21349833DOI: 10.1074/jbc.M110.192435 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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