3QGW

Crystal Structure of ITK kinase bound to an inhibitor

Summary for 3QGW

Entry DOI	10.2210/pdb3qgw/pdb
Related	1SM2 1SNU 1SNX
Descriptor	Tyrosine-protein kinase ITK/TSK, 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide, N-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)benzamide, ... (4 entities in total)
Functional Keywords	protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane (By similarity): Q08881
Total number of polymer chains	2
Total formula weight	65712.00
Authors	Brown, K.,Cheetham, G.M.T. (deposition date: 2011-01-25, release date: 2011-06-22, Last modification date: 2024-03-20)
Primary citation	Charrier, J.D.,Miller, A.,Kay, D.P.,Brenchley, G.,Twin, H.C.,Collier, P.N.,Ramaya, S.,Keily, S.B.,Durrant, S.J.,Knegtel, R.M.,Tanner, A.J.,Brown, K.,Curnock, A.P.,Jimenez, J.M. Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors J.Med.Chem., 54:2341-2350, 2011 Cited by PubMed: 21391610 DOI: 10.1021/jm101499u PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation