3QGT

Crystal structure of Wild-type PfDHFR-TS COMPLEXED WITH NADPH, dUMP AND PYRIMETHAMINE

3QGT の概要

• エントリーDOI: 10.2210/pdb3qgt/pdb
• 関連するPDBエントリー: 1J3I 1J3J 1J3K 3DG8 3DGA 3JSU 3QFX 3QG2 3RG9
• 分子名称: Bifunctional dihydrofolate reductase-thymidylate synthase, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: malarial dhfr-ts antifolate complex, rossmann fold, reductase, dihydrofolate binding, dump binding, nadph binding, oxidoreductase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 146260.63

構造登録者

Chitnumsub, P.,Yuthavong, Y. (登録日: 2011-01-24, 公開日: 2011-06-29, 最終更新日: 2023-11-01)

• 主引用文献: Vanichtanankul, J.,Taweechai, S.,Yuvaniyama, J.,Vilaivan, T.,Chitnumsub, P.,Kamchonwongpaisan, S.,Yuthavong, Y.; Trypanosomal dihydrofolate reductase reveals natural antifolate resistance; Acs Chem.Biol., 6:905-911, 2011; PubMed: 21650210; DOI: 10.1021/cb200124r

実験手法

X-RAY DIFFRACTION (2.3 Å)