3QGT

Crystal structure of Wild-type PfDHFR-TS COMPLEXED WITH NADPH, dUMP AND PYRIMETHAMINE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Bifunctional dihydrofolate reductase-thymidylate synthase	polymer	608	71828.0	2	UniProt (A7UD81) Pfam (PF00186) Pfam (PF00303)	Plasmodium falciparum
2	C, F (A, B)	5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE	non-polymer		248.7	2	Chemie (CP6)
3	D, G (A, B)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
4	E, H (A, B)	2'-DEOXYURIDINE 5'-MONOPHOSPHATE	non-polymer		308.2	2	Chemie (UMP)
5	I, J (A, B)	water	water		18.0	313	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	143656.0
Non-Polymers*	Number of molecules	6
	Total formula weight	2604.6
All*	Total formula weight	146260.6

*Water molecules are not included.