3QGI

Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase genotype 1a complex with N-[(2S)-butan-2-yl]-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide

3QGI の概要

• エントリーDOI: 10.2210/pdb3qgi/pdb
• 関連するPDBエントリー: 3QGD 3QGE 3QGF 3QGG 3QGH
• 分子名称: RNA-directed RNA polymerase, N-[(2S)-butan-2-yl]-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: ns5b, polymerase, hcv, fingers, palm, thumb, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Hepatitis C virus subtype 1a
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 65012.28

構造登録者

Sheriff, S. (登録日: 2011-01-24, 公開日: 2011-04-20, 最終更新日: 2024-04-03)

• 主引用文献: Gentles, R.G.,Sheriff, S.,Beno, B.R.,Wan, C.,Kish, K.,Ding, M.,Zheng, X.,Chupak, L.,Poss, M.A.,Witmer, M.R.,Morin, P.,Wang, Y.K.,Rigat, K.,Lemm, J.,Voss, S.,Liu, M.,Pelosi, L.,Roberts, S.B.,Gao, M.,Kadow, J.F.; Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.; Bioorg.Med.Chem.Lett., 21:2212-2215, 2011; PubMed: 21441029; DOI: 10.1016/j.bmcl.2011.03.011

実験手法

X-RAY DIFFRACTION (1.8 Å)