3QEQ

The complex between TCR DMF4 and human Class I MHC HLA-A2 with the bound MART-1(27-35) nonameric peptide

3QEQ の概要

• エントリーDOI: 10.2210/pdb3qeq/pdb
• 関連するPDBエントリー: 3QDG 3QDJ 3QDM 3QEU
• 分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, MART-1(27-35) peptide, ... (6 entities in total)
• 機能のキーワード: mart-1 peptide, nonapeptide, mhc class i, hla-a2, tcr dmf5, tcr dmf4, cross-reactivity, cancer, melanoma, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted . Note=(Microbial infection) In the presence of M: P61769
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 93346.43

構造登録者

Borbulevych, O.Y.,Baker, B.M. (登録日: 2011-01-20, 公開日: 2011-07-06, 最終更新日: 2023-09-13)

• 主引用文献: Borbulevych, O.Y.,Santhanagopolan, S.M.,Hossain, M.,Baker, B.M.; TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms.; J.Immunol., 187:2453-2463, 2011; PubMed: 21795600; DOI: 10.4049/jimmunol.1101268

実験手法

X-RAY DIFFRACTION (2.59 Å)