3QBT

Crystal structure of OCRL1 540-678 in complex with Rab8a:GppNHp

Summary for 3QBT

Entry DOI	10.2210/pdb3qbt/pdb
Descriptor	Ras-related protein Rab-8A, Inositol polyphosphate 5-phosphatase OCRL-1, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	protein transport, vesicular trafficking, gtpase, lowe syndrome, immunoglobulin fold, rab8a, ocrl1, endocytosis, clathrin, appl1, phosphoinositide, ash, rhogap, protein transport-hydrolase complex, protein transport/hydrolase
Biological source	Homo sapiens (human) More
Cellular location	Endosome: P61006 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): Q01968
Total number of polymer chains	8
Total formula weight	148644.94
Authors	Hou, X.,Hagemann, N.,Schoebel, S.,Blankenfeldt, W.,Goody, R.S.,Erdmann, K.S.,Itzen, A. (deposition date: 2011-01-14, release date: 2011-03-23, Last modification date: 2023-09-13)
Primary citation	Hou, X.,Hagemann, N.,Schoebel, S.,Blankenfeldt, W.,Goody, R.S.,Erdmann, K.S.,Itzen, A. A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. Embo J., 30:1659-1670, 2011 Cited by PubMed: 21378754 DOI: 10.1038/emboj.2011.60 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation