3QBT

Crystal structure of OCRL1 540-678 in complex with Rab8a:GppNHp

3QBT の概要

• エントリーDOI: 10.2210/pdb3qbt/pdb
• 分子名称: Ras-related protein Rab-8A, Inositol polyphosphate 5-phosphatase OCRL-1, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: protein transport, vesicular trafficking, gtpase, lowe syndrome, immunoglobulin fold, rab8a, ocrl1, endocytosis, clathrin, appl1, phosphoinositide, ash, rhogap, protein transport-hydrolase complex, protein transport/hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Endosome: P61006; Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): Q01968
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 148644.94

構造登録者

Hou, X.,Hagemann, N.,Schoebel, S.,Blankenfeldt, W.,Goody, R.S.,Erdmann, K.S.,Itzen, A. (登録日: 2011-01-14, 公開日: 2011-03-23, 最終更新日: 2023-09-13)

• 主引用文献: Hou, X.,Hagemann, N.,Schoebel, S.,Blankenfeldt, W.,Goody, R.S.,Erdmann, K.S.,Itzen, A.; A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1.; Embo J., 30:1659-1670, 2011; PubMed: 21378754; DOI: 10.1038/emboj.2011.60

実験手法

X-RAY DIFFRACTION (2 Å)