3Q8W
A b-aminoacyl containing thiazolidine derivative and DPPIV complex
Summary for 3Q8W
Entry DOI | 10.2210/pdb3q8w/pdb |
Descriptor | Dipeptidyl peptidase 4, N-(4-{[({(2R)-3-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-thiazolidin-2-yl}carbonyl)amino]methyl}phenyl)-D-valine (2 entities in total) |
Functional Keywords | rossmann fold, hydrolase, membrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Dipeptidyl peptidase 4 soluble form: Secreted. Cell membrane; Single-pass type II membrane protein: P27487 |
Total number of polymer chains | 2 |
Total formula weight | 171267.69 |
Authors | Lee, J.O.,Song, D.H. (deposition date: 2011-01-07, release date: 2011-03-16, Last modification date: 2011-07-13) |
Primary citation | Park, W.S.,Kang, S.K.,Jun, M.A.,Shin, M.S.,Kim, K.Y.,Rhee, S.D.,Bae, M.A.,Kim, M.S.,Kim, K.R.,Kang, N.S.,Yoo, S.E.,Lee, J.O.,Song, D.H.,Silinski, P.,Schneider, S.E.,Ahn, J.H.,Kim, S.S. Discovery of b-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors To be Published, |
Experimental method | X-RAY DIFFRACTION (3.64 Å) |
Structure validation
Download full validation report