3Q7J

Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development

Summary for 3Q7J

Entry DOI	10.2210/pdb3q7j/pdb
Descriptor	Tricorn protease-interacting factor F3, ZINC ION, L-phenylalanyl-N6-[(benzyloxy)carbonyl]-N1-hydroxy-L-lysinamide, ... (4 entities in total)
Functional Keywords	trf3, inhibitor fbo, aminopeptidase, inhibitor binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Thermoplasma acidophilum
Cellular location	Cytoplasm: O93655
Total number of polymer chains	2
Total formula weight	179530.81
Authors	Su, J.,Wang, Q.,Feng, J.,Zhang, C.,Zhu, D.,We, T.,Xu, W.,Gu, L. (deposition date: 2011-01-05, release date: 2011-07-27, Last modification date: 2023-11-01)
Primary citation	Su, J.,Wang, Q.,Feng, J.,Zhang, C.,Zhu, D.,Wei, T.,Xu, W.,Gu, L. Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development Bioorg.Med.Chem., 19:2991-2996, 2011 Cited by PubMed: 21493078 DOI: 10.1016/j.bmc.2011.03.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.91 Å)

Structure validation