3Q7J

Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development

3Q7J の概要

• エントリーDOI: 10.2210/pdb3q7j/pdb
• 分子名称: Tricorn protease-interacting factor F3, ZINC ION, L-phenylalanyl-N6-[(benzyloxy)carbonyl]-N1-hydroxy-L-lysinamide, ... (4 entities in total)
• 機能のキーワード: trf3, inhibitor fbo, aminopeptidase, inhibitor binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Thermoplasma acidophilum
• 細胞内の位置: Cytoplasm: O93655
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 179530.81

構造登録者

Su, J.,Wang, Q.,Feng, J.,Zhang, C.,Zhu, D.,We, T.,Xu, W.,Gu, L. (登録日: 2011-01-05, 公開日: 2011-07-27, 最終更新日: 2023-11-01)

• 主引用文献: Su, J.,Wang, Q.,Feng, J.,Zhang, C.,Zhu, D.,Wei, T.,Xu, W.,Gu, L.; Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development; Bioorg.Med.Chem., 19:2991-2996, 2011; PubMed: 21493078; DOI: 10.1016/j.bmc.2011.03.028

実験手法

X-RAY DIFFRACTION (2.91 Å)