3Q6W

Structure of dually-phosphorylated MET receptor kinase in complex with an MK-2461 analog with specificity for the activated receptor

Summary for 3Q6W

• Entry DOI: 10.2210/pdb3q6w/pdb
• Related: 3Q6U
• Descriptor: Hepatocyte growth factor receptor, 3-{5-oxo-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}-N-(pyridin-2-ylmethyl)propanamide (3 entities in total)
• Functional Keywords: tyrosine kinase, two phosphotyrosine resiudes, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• Total number of polymer chains: 1
• Total formula weight: 35631.98

Authors

Soisson, S.M.,Rickert, K.W.,Patel, S.B.,Lumb, K.J. (deposition date: 2011-01-03, release date: 2011-01-19, Last modification date: 2017-11-08)

• Primary citation: Rickert, K.W.,Patel, S.B.,Allison, T.J.,Byrne, N.J.,Darke, P.L.,Ford, R.E.,Guerin, D.J.,Hall, D.L.,Kornienko, M.,Lu, J.,Munshi, S.K.,Reid, J.C.,Shipman, J.M.,Stanton, E.F.,Wilson, K.J.,Young, J.R.,Soisson, S.M.,Lumb, K.J.; Structural basis for selective small molecule kinase inhibition of activated c-Met.; J.Biol.Chem., 286:11218-11225, 2011; PubMed: 21247903; DOI: 10.1074/jbc.M110.204404

Experimental method

X-RAY DIFFRACTION (1.75 Å)