Reduced sweetness of a monellin (MNEI) mutant results from increased protein flexibility and disruption of a distant poly-(L-proline) II helix

Summary for 3Q2P

Related3PYJ 3PXM 2O9U
DescriptorMonellin chain B/Monellin chain A chimeric protein, SODIUM ION (3 entities in total)
Functional Keywordssweet protein, sweet receptor, t1r2:t1r3, plant protein
Biological sourceDioscoreophyllum cumminsii (Serendipity berry)
Total number of polymer chains4
Total molecular weight45643.07
Templeton, C.M.,Hobbs, J.R.,Munger, S.D.,Conn, G.L. (deposition date: 2010-12-20, release date: 2011-04-06, Last modification date: 2017-08-02)
Primary citation
Templeton, C.M.,Ostovar Pour, S.,Hobbs, J.R.,Blanch, E.W.,Munger, S.D.,Conn, G.L.
Reduced Sweetness of a Monellin (MNEI) Mutant Results from Increased Protein Flexibility and Disruption of a Distant Poly-(L-Proline) II Helix.
Chem Senses, 36:425-434, 2011
PubMed: 21343241 (PDB entries with the same primary citation)
DOI: 10.1093/chemse/bjr007
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.236901.8%0.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution