3Q2H
Adamts1 in complex with N-hydroxyformamide inhibitors of ADAM-TS4
Summary for 3Q2H
Entry DOI | 10.2210/pdb3q2h/pdb |
Related | 3Q2G |
Descriptor | A disintegrin and metalloproteinase with thrombospondin motifs 1, ZINC ION, CADMIUM ION, ... (8 entities in total) |
Functional Keywords | adamts1 zn-metalloprotease, disintegrin, metalloproteinase, thrombospondin motifs, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix (By similarity): Q9UHI8 |
Total number of polymer chains | 2 |
Total formula weight | 67747.36 |
Authors | Gerhardt, S.,Hargreaves, D. (deposition date: 2010-12-20, release date: 2011-03-30, Last modification date: 2023-11-01) |
Primary citation | De Savi, C.,Pape, A.,Cumming, J.G.,Ting, A.,Smith, P.D.,Burrows, J.N.,Mills, M.,Davies, C.,Lamont, S.,Milne, D.,Cook, C.,Moore, P.,Sawyer, Y.,Gerhardt, S. The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis Bioorg.Med.Chem.Lett., 21:1376-1381, 2011 Cited by PubMed: 21300546DOI: 10.1016/j.bmcl.2011.01.036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
Download full validation report