3Q1E
Crystal structure of Y116T/I16A double mutant of 5-hydroxyisourate hydrolase in complex with T4
Summary for 3Q1E
| Entry DOI | 10.2210/pdb3q1e/pdb |
| Related | 2H1X 2H6U 3IWV |
| Descriptor | 5-hydroxyisourate hydrolase, 3,5,3',5'-TETRAIODO-L-THYRONINE (3 entities in total) |
| Functional Keywords | hiuase, transthyretin, trp, thyroid hormones, molecular evolution, purine metabolism, greek key beta-barrel, hydrolase, point mutation, peroxisome |
| Biological source | Danio rerio (zebra fish) |
| Total number of polymer chains | 4 |
| Total formula weight | 54241.64 |
| Authors | Cendron, L.,Ramazzina, I.,Percudani, R.,Zanotti, G.,Berni, R. (deposition date: 2010-12-17, release date: 2011-05-04, Last modification date: 2023-11-15) |
| Primary citation | Cendron, L.,Ramazzina, I.,Percudani, R.,Rasore, C.,Zanotti, G.,Berni, R. Probing the evolution of hydroxyisourate hydrolase into transthyretin through active-site redesign. J.Mol.Biol., 409:504-512, 2011 Cited by PubMed: 21515285DOI: 10.1016/j.jmb.2011.04.022 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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