3Q11

Crystals Structure of Aspartate beta-Semialdehyde Dehydrogenase from Streptococcus pneumoniae with NADP and aspartyl beta-difluorophosphonate

Summary for 3Q11

• Entry DOI: 10.2210/pdb3q11/pdb
• Related: 3PYX 3PZB 3PZR 3Q0E 3Q1L
• Descriptor: Aspartate-semialdehyde dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5,5-difluoro-4-oxo-5-phosphono-D-norvaline, ... (6 entities in total)
• Functional Keywords: nadp, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Streptococcus pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 82391.37

Authors

Pavlovsky, A.G.,Viola, R.E.,Faehnle, C.R. (deposition date: 2010-12-16, release date: 2012-01-04, Last modification date: 2024-02-21)

• Primary citation: Pavlovsky, A.G.,Liu, X.,Faehnle, C.R.,Potente, N.,Viola, R.E.; Structural Characterization of Inhibitors with Selectivity against Members of a Homologous Enzyme Family.; Chem.Biol.Drug Des., 79:128-136, 2012; PubMed: 22039970; DOI: 10.1111/j.1747-0285.2011.01267.x

Experimental method

X-RAY DIFFRACTION (1.8 Å)