3PWR

HIV-1 Protease Mutant L76V complexed with Saquinavir

3PWR の概要

• エントリーDOI: 10.2210/pdb3pwr/pdb
• 関連するPDBエントリー: 3OXC
• 関連するBIRD辞書のPRD_ID: PRD_000454
• 分子名称: Protease, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: hiv-1, protease, mutation l76v, saquinavir, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22896.35

構造登録者

Zhang, Y.,Weber, I.T. (登録日: 2010-12-08, 公開日: 2011-04-20, 最終更新日: 2023-09-13)

• 主引用文献: Louis, J.M.,Zhang, Y.,Sayer, J.M.,Wang, Y.F.,Harrison, R.W.,Weber, I.T.; The L76V Drug Resistance Mutation Decreases the Dimer Stability and Rate of Autoprocessing of HIV-1 Protease by Reducing Internal Hydrophobic Contacts.; Biochemistry, 50:4786-4795, 2011; PubMed: 21446746; DOI: 10.1021/bi200033z

実験手法

X-RAY DIFFRACTION (1.45 Å)