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3PVO

Monoclinic form of Human C-Reactive Protein

Summary for 3PVO
Entry DOI10.2210/pdb3pvo/pdb
Related1LJ7 3PVN
DescriptorC-Reactive Protein, CALCIUM ION (3 entities in total)
Functional Keywordspentraxin family, immune system
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P02741
Total number of polymer chains20
Total formula weight462963.90
Authors
Guillon, C.,Mavoungou Bigouagou, U.,Jeannin, P.,Delneste, Y.,Gouet, P. (deposition date: 2010-12-07, release date: 2012-01-11, Last modification date: 2024-10-09)
Primary citationGuillon, C.,Bigouagou, U.M.,Folio, C.,Jeannin, P.,Delneste, Y.,Gouet, P.
A Staggered Decameric Assembly of Human C-Reactive Protein Stabilized by Zinc Ions Revealed by X-ray Crystallography.
Protein Pept.Lett., 22:248-255, 2014
Cited by
PubMed Abstract: Human C-reactive protein (CRP) is an acute phase protein, which harbours both host defence and scavenging properties. In this study, we obtained two new crystal forms of CRP, where CRP forms a symmetric, staggered dimer of pentamers. In one of these structures, obtained in the presence of HIV-1 Tat protein, this dimer of pentamers is stabilized by two zinc ions trapped within a cleft of the effector face of CRP. These two decameric interfaces involve complementary surfaces of CRP pentamers and bury a large area of ~2000 Å(2) per pentamer, suggesting a biological role of this interface. These two novel decameric interfaces and the involvement of zinc might have important consequences in the understanding of CRP biological functions.
PubMed: 25552313
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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