3PVN

Triclinic form of Human C-Reactive Protein in complex with Zinc

3PVN の概要

• エントリーDOI: 10.2210/pdb3pvn/pdb
• 関連するPDBエントリー: 1LJ7 3PVO
• 分子名称: C-reactive protein, CALCIUM ION, ZINC ION, ... (4 entities in total)
• 機能のキーワード: pentraxin family, immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02741
• タンパク質・核酸の鎖数: 20
• 化学式量合計: 463290.95

構造登録者

Guillon, C.,Mavoungou Bigouagou, U.,Jeannin, P.,Delneste, Y.,Gouet, P. (登録日: 2010-12-07, 公開日: 2012-01-11, 最終更新日: 2024-10-30)

主引用文献

Guillon, C.,Bigouagou, U.M.,Folio, C.,Jeannin, P.,Delneste, Y.,Gouet, P.
A Staggered Decameric Assembly of Human C-Reactive Protein Stabilized by Zinc Ions Revealed by X-ray Crystallography.
Protein Pept.Lett., 22:248-255, 2014

PubMed Abstract: Human C-reactive protein (CRP) is an acute phase protein, which harbours both host defence and scavenging properties. In this study, we obtained two new crystal forms of CRP, where CRP forms a symmetric, staggered dimer of pentamers. In one of these structures, obtained in the presence of HIV-1 Tat protein, this dimer of pentamers is stabilized by two zinc ions trapped within a cleft of the effector face of CRP. These two decameric interfaces involve complementary surfaces of CRP pentamers and bury a large area of ~2000 Å(2) per pentamer, suggesting a biological role of this interface. These two novel decameric interfaces and the involvement of zinc might have important consequences in the understanding of CRP biological functions.

PubMed: 25552313

実験手法

X-RAY DIFFRACTION (1.98 Å)