3PVN

Triclinic form of Human C-Reactive Protein in complex with Zinc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001849	molecular_function	complement component C1q complex binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006953	biological_process	acute-phase response
A	0006954	biological_process	inflammatory response
A	0008228	biological_process	opsonization
A	0010628	biological_process	positive regulation of gene expression
A	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
A	0010888	biological_process	negative regulation of lipid storage
A	0030169	molecular_function	low-density lipoprotein particle binding
A	0032677	biological_process	regulation of interleukin-8 production
A	0032930	biological_process	positive regulation of superoxide anion generation
A	0032945	biological_process	negative regulation of mononuclear cell proliferation
A	0033265	molecular_function	choline binding
A	0042310	biological_process	vasoconstriction
A	0042802	molecular_function	identical protein binding
A	0045087	biological_process	innate immune response
A	0046790	molecular_function	virion binding
A	0046872	molecular_function	metal ion binding
A	0050750	molecular_function	low-density lipoprotein particle receptor binding
A	0050830	biological_process	defense response to Gram-positive bacterium
B	0001849	molecular_function	complement component C1q complex binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006953	biological_process	acute-phase response
B	0006954	biological_process	inflammatory response
B	0008228	biological_process	opsonization
B	0010628	biological_process	positive regulation of gene expression
B	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
B	0010888	biological_process	negative regulation of lipid storage
B	0030169	molecular_function	low-density lipoprotein particle binding
B	0032677	biological_process	regulation of interleukin-8 production
B	0032930	biological_process	positive regulation of superoxide anion generation
B	0032945	biological_process	negative regulation of mononuclear cell proliferation
B	0033265	molecular_function	choline binding
B	0042310	biological_process	vasoconstriction
B	0042802	molecular_function	identical protein binding
B	0045087	biological_process	innate immune response
B	0046790	molecular_function	virion binding
B	0046872	molecular_function	metal ion binding
B	0050750	molecular_function	low-density lipoprotein particle receptor binding
B	0050830	biological_process	defense response to Gram-positive bacterium
C	0001849	molecular_function	complement component C1q complex binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006953	biological_process	acute-phase response
C	0006954	biological_process	inflammatory response
C	0008228	biological_process	opsonization
C	0010628	biological_process	positive regulation of gene expression
C	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
C	0010888	biological_process	negative regulation of lipid storage
C	0030169	molecular_function	low-density lipoprotein particle binding
C	0032677	biological_process	regulation of interleukin-8 production
C	0032930	biological_process	positive regulation of superoxide anion generation
C	0032945	biological_process	negative regulation of mononuclear cell proliferation
C	0033265	molecular_function	choline binding
C	0042310	biological_process	vasoconstriction
C	0042802	molecular_function	identical protein binding
C	0045087	biological_process	innate immune response
C	0046790	molecular_function	virion binding
C	0046872	molecular_function	metal ion binding
C	0050750	molecular_function	low-density lipoprotein particle receptor binding
C	0050830	biological_process	defense response to Gram-positive bacterium
D	0001849	molecular_function	complement component C1q complex binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006953	biological_process	acute-phase response
D	0006954	biological_process	inflammatory response
D	0008228	biological_process	opsonization
D	0010628	biological_process	positive regulation of gene expression
D	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
D	0010888	biological_process	negative regulation of lipid storage
D	0030169	molecular_function	low-density lipoprotein particle binding
D	0032677	biological_process	regulation of interleukin-8 production
D	0032930	biological_process	positive regulation of superoxide anion generation
D	0032945	biological_process	negative regulation of mononuclear cell proliferation
D	0033265	molecular_function	choline binding
D	0042310	biological_process	vasoconstriction
D	0042802	molecular_function	identical protein binding
D	0045087	biological_process	innate immune response
D	0046790	molecular_function	virion binding
D	0046872	molecular_function	metal ion binding
D	0050750	molecular_function	low-density lipoprotein particle receptor binding
D	0050830	biological_process	defense response to Gram-positive bacterium
E	0001849	molecular_function	complement component C1q complex binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006953	biological_process	acute-phase response
E	0006954	biological_process	inflammatory response
E	0008228	biological_process	opsonization
E	0010628	biological_process	positive regulation of gene expression
E	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
E	0010888	biological_process	negative regulation of lipid storage
E	0030169	molecular_function	low-density lipoprotein particle binding
E	0032677	biological_process	regulation of interleukin-8 production
E	0032930	biological_process	positive regulation of superoxide anion generation
E	0032945	biological_process	negative regulation of mononuclear cell proliferation
E	0033265	molecular_function	choline binding
E	0042310	biological_process	vasoconstriction
E	0042802	molecular_function	identical protein binding
E	0045087	biological_process	innate immune response
E	0046790	molecular_function	virion binding
E	0046872	molecular_function	metal ion binding
E	0050750	molecular_function	low-density lipoprotein particle receptor binding
E	0050830	biological_process	defense response to Gram-positive bacterium
F	0001849	molecular_function	complement component C1q complex binding
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0006953	biological_process	acute-phase response
F	0006954	biological_process	inflammatory response
F	0008228	biological_process	opsonization
F	0010628	biological_process	positive regulation of gene expression
F	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
F	0010888	biological_process	negative regulation of lipid storage
F	0030169	molecular_function	low-density lipoprotein particle binding
F	0032677	biological_process	regulation of interleukin-8 production
F	0032930	biological_process	positive regulation of superoxide anion generation
F	0032945	biological_process	negative regulation of mononuclear cell proliferation
F	0033265	molecular_function	choline binding
F	0042310	biological_process	vasoconstriction
F	0042802	molecular_function	identical protein binding
F	0045087	biological_process	innate immune response
F	0046790	molecular_function	virion binding
F	0046872	molecular_function	metal ion binding
F	0050750	molecular_function	low-density lipoprotein particle receptor binding
F	0050830	biological_process	defense response to Gram-positive bacterium
G	0001849	molecular_function	complement component C1q complex binding
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0006953	biological_process	acute-phase response
G	0006954	biological_process	inflammatory response
G	0008228	biological_process	opsonization
G	0010628	biological_process	positive regulation of gene expression
G	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
G	0010888	biological_process	negative regulation of lipid storage
G	0030169	molecular_function	low-density lipoprotein particle binding
G	0032677	biological_process	regulation of interleukin-8 production
G	0032930	biological_process	positive regulation of superoxide anion generation
G	0032945	biological_process	negative regulation of mononuclear cell proliferation
G	0033265	molecular_function	choline binding
G	0042310	biological_process	vasoconstriction
G	0042802	molecular_function	identical protein binding
G	0045087	biological_process	innate immune response
G	0046790	molecular_function	virion binding
G	0046872	molecular_function	metal ion binding
G	0050750	molecular_function	low-density lipoprotein particle receptor binding
G	0050830	biological_process	defense response to Gram-positive bacterium
H	0001849	molecular_function	complement component C1q complex binding
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0006953	biological_process	acute-phase response
H	0006954	biological_process	inflammatory response
H	0008228	biological_process	opsonization
H	0010628	biological_process	positive regulation of gene expression
H	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
H	0010888	biological_process	negative regulation of lipid storage
H	0030169	molecular_function	low-density lipoprotein particle binding
H	0032677	biological_process	regulation of interleukin-8 production
H	0032930	biological_process	positive regulation of superoxide anion generation
H	0032945	biological_process	negative regulation of mononuclear cell proliferation
H	0033265	molecular_function	choline binding
H	0042310	biological_process	vasoconstriction
H	0042802	molecular_function	identical protein binding
H	0045087	biological_process	innate immune response
H	0046790	molecular_function	virion binding
H	0046872	molecular_function	metal ion binding
H	0050750	molecular_function	low-density lipoprotein particle receptor binding
H	0050830	biological_process	defense response to Gram-positive bacterium
I	0001849	molecular_function	complement component C1q complex binding
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0006953	biological_process	acute-phase response
I	0006954	biological_process	inflammatory response
I	0008228	biological_process	opsonization
I	0010628	biological_process	positive regulation of gene expression
I	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
I	0010888	biological_process	negative regulation of lipid storage
I	0030169	molecular_function	low-density lipoprotein particle binding
I	0032677	biological_process	regulation of interleukin-8 production
I	0032930	biological_process	positive regulation of superoxide anion generation
I	0032945	biological_process	negative regulation of mononuclear cell proliferation
I	0033265	molecular_function	choline binding
I	0042310	biological_process	vasoconstriction
I	0042802	molecular_function	identical protein binding
I	0045087	biological_process	innate immune response
I	0046790	molecular_function	virion binding
I	0046872	molecular_function	metal ion binding
I	0050750	molecular_function	low-density lipoprotein particle receptor binding
I	0050830	biological_process	defense response to Gram-positive bacterium
J	0001849	molecular_function	complement component C1q complex binding
J	0005509	molecular_function	calcium ion binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0006953	biological_process	acute-phase response
J	0006954	biological_process	inflammatory response
J	0008228	biological_process	opsonization
J	0010628	biological_process	positive regulation of gene expression
J	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
J	0010888	biological_process	negative regulation of lipid storage
J	0030169	molecular_function	low-density lipoprotein particle binding
J	0032677	biological_process	regulation of interleukin-8 production
J	0032930	biological_process	positive regulation of superoxide anion generation
J	0032945	biological_process	negative regulation of mononuclear cell proliferation
J	0033265	molecular_function	choline binding
J	0042310	biological_process	vasoconstriction
J	0042802	molecular_function	identical protein binding
J	0045087	biological_process	innate immune response
J	0046790	molecular_function	virion binding
J	0046872	molecular_function	metal ion binding
J	0050750	molecular_function	low-density lipoprotein particle receptor binding
J	0050830	biological_process	defense response to Gram-positive bacterium
K	0001849	molecular_function	complement component C1q complex binding
K	0005509	molecular_function	calcium ion binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0006953	biological_process	acute-phase response
K	0006954	biological_process	inflammatory response
K	0008228	biological_process	opsonization
K	0010628	biological_process	positive regulation of gene expression
K	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
K	0010888	biological_process	negative regulation of lipid storage
K	0030169	molecular_function	low-density lipoprotein particle binding
K	0032677	biological_process	regulation of interleukin-8 production
K	0032930	biological_process	positive regulation of superoxide anion generation
K	0032945	biological_process	negative regulation of mononuclear cell proliferation
K	0033265	molecular_function	choline binding
K	0042310	biological_process	vasoconstriction
K	0042802	molecular_function	identical protein binding
K	0045087	biological_process	innate immune response
K	0046790	molecular_function	virion binding
K	0046872	molecular_function	metal ion binding
K	0050750	molecular_function	low-density lipoprotein particle receptor binding
K	0050830	biological_process	defense response to Gram-positive bacterium
L	0001849	molecular_function	complement component C1q complex binding
L	0005509	molecular_function	calcium ion binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0006953	biological_process	acute-phase response
L	0006954	biological_process	inflammatory response
L	0008228	biological_process	opsonization
L	0010628	biological_process	positive regulation of gene expression
L	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
L	0010888	biological_process	negative regulation of lipid storage
L	0030169	molecular_function	low-density lipoprotein particle binding
L	0032677	biological_process	regulation of interleukin-8 production
L	0032930	biological_process	positive regulation of superoxide anion generation
L	0032945	biological_process	negative regulation of mononuclear cell proliferation
L	0033265	molecular_function	choline binding
L	0042310	biological_process	vasoconstriction
L	0042802	molecular_function	identical protein binding
L	0045087	biological_process	innate immune response
L	0046790	molecular_function	virion binding
L	0046872	molecular_function	metal ion binding
L	0050750	molecular_function	low-density lipoprotein particle receptor binding
L	0050830	biological_process	defense response to Gram-positive bacterium
M	0001849	molecular_function	complement component C1q complex binding
M	0005509	molecular_function	calcium ion binding
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0006953	biological_process	acute-phase response
M	0006954	biological_process	inflammatory response
M	0008228	biological_process	opsonization
M	0010628	biological_process	positive regulation of gene expression
M	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
M	0010888	biological_process	negative regulation of lipid storage
M	0030169	molecular_function	low-density lipoprotein particle binding
M	0032677	biological_process	regulation of interleukin-8 production
M	0032930	biological_process	positive regulation of superoxide anion generation
M	0032945	biological_process	negative regulation of mononuclear cell proliferation
M	0033265	molecular_function	choline binding
M	0042310	biological_process	vasoconstriction
M	0042802	molecular_function	identical protein binding
M	0045087	biological_process	innate immune response
M	0046790	molecular_function	virion binding
M	0046872	molecular_function	metal ion binding
M	0050750	molecular_function	low-density lipoprotein particle receptor binding
M	0050830	biological_process	defense response to Gram-positive bacterium
N	0001849	molecular_function	complement component C1q complex binding
N	0005509	molecular_function	calcium ion binding
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0006953	biological_process	acute-phase response
N	0006954	biological_process	inflammatory response
N	0008228	biological_process	opsonization
N	0010628	biological_process	positive regulation of gene expression
N	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
N	0010888	biological_process	negative regulation of lipid storage
N	0030169	molecular_function	low-density lipoprotein particle binding
N	0032677	biological_process	regulation of interleukin-8 production
N	0032930	biological_process	positive regulation of superoxide anion generation
N	0032945	biological_process	negative regulation of mononuclear cell proliferation
N	0033265	molecular_function	choline binding
N	0042310	biological_process	vasoconstriction
N	0042802	molecular_function	identical protein binding
N	0045087	biological_process	innate immune response
N	0046790	molecular_function	virion binding
N	0046872	molecular_function	metal ion binding
N	0050750	molecular_function	low-density lipoprotein particle receptor binding
N	0050830	biological_process	defense response to Gram-positive bacterium
O	0001849	molecular_function	complement component C1q complex binding
O	0005509	molecular_function	calcium ion binding
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005615	cellular_component	extracellular space
O	0006953	biological_process	acute-phase response
O	0006954	biological_process	inflammatory response
O	0008228	biological_process	opsonization
O	0010628	biological_process	positive regulation of gene expression
O	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
O	0010888	biological_process	negative regulation of lipid storage
O	0030169	molecular_function	low-density lipoprotein particle binding
O	0032677	biological_process	regulation of interleukin-8 production
O	0032930	biological_process	positive regulation of superoxide anion generation
O	0032945	biological_process	negative regulation of mononuclear cell proliferation
O	0033265	molecular_function	choline binding
O	0042310	biological_process	vasoconstriction
O	0042802	molecular_function	identical protein binding
O	0045087	biological_process	innate immune response
O	0046790	molecular_function	virion binding
O	0046872	molecular_function	metal ion binding
O	0050750	molecular_function	low-density lipoprotein particle receptor binding
O	0050830	biological_process	defense response to Gram-positive bacterium
P	0001849	molecular_function	complement component C1q complex binding
P	0005509	molecular_function	calcium ion binding
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0006953	biological_process	acute-phase response
P	0006954	biological_process	inflammatory response
P	0008228	biological_process	opsonization
P	0010628	biological_process	positive regulation of gene expression
P	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
P	0010888	biological_process	negative regulation of lipid storage
P	0030169	molecular_function	low-density lipoprotein particle binding
P	0032677	biological_process	regulation of interleukin-8 production
P	0032930	biological_process	positive regulation of superoxide anion generation
P	0032945	biological_process	negative regulation of mononuclear cell proliferation
P	0033265	molecular_function	choline binding
P	0042310	biological_process	vasoconstriction
P	0042802	molecular_function	identical protein binding
P	0045087	biological_process	innate immune response
P	0046790	molecular_function	virion binding
P	0046872	molecular_function	metal ion binding
P	0050750	molecular_function	low-density lipoprotein particle receptor binding
P	0050830	biological_process	defense response to Gram-positive bacterium
Q	0001849	molecular_function	complement component C1q complex binding
Q	0005509	molecular_function	calcium ion binding
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0006953	biological_process	acute-phase response
Q	0006954	biological_process	inflammatory response
Q	0008228	biological_process	opsonization
Q	0010628	biological_process	positive regulation of gene expression
Q	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
Q	0010888	biological_process	negative regulation of lipid storage
Q	0030169	molecular_function	low-density lipoprotein particle binding
Q	0032677	biological_process	regulation of interleukin-8 production
Q	0032930	biological_process	positive regulation of superoxide anion generation
Q	0032945	biological_process	negative regulation of mononuclear cell proliferation
Q	0033265	molecular_function	choline binding
Q	0042310	biological_process	vasoconstriction
Q	0042802	molecular_function	identical protein binding
Q	0045087	biological_process	innate immune response
Q	0046790	molecular_function	virion binding
Q	0046872	molecular_function	metal ion binding
Q	0050750	molecular_function	low-density lipoprotein particle receptor binding
Q	0050830	biological_process	defense response to Gram-positive bacterium
R	0001849	molecular_function	complement component C1q complex binding
R	0005509	molecular_function	calcium ion binding
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005615	cellular_component	extracellular space
R	0006953	biological_process	acute-phase response
R	0006954	biological_process	inflammatory response
R	0008228	biological_process	opsonization
R	0010628	biological_process	positive regulation of gene expression
R	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
R	0010888	biological_process	negative regulation of lipid storage
R	0030169	molecular_function	low-density lipoprotein particle binding
R	0032677	biological_process	regulation of interleukin-8 production
R	0032930	biological_process	positive regulation of superoxide anion generation
R	0032945	biological_process	negative regulation of mononuclear cell proliferation
R	0033265	molecular_function	choline binding
R	0042310	biological_process	vasoconstriction
R	0042802	molecular_function	identical protein binding
R	0045087	biological_process	innate immune response
R	0046790	molecular_function	virion binding
R	0046872	molecular_function	metal ion binding
R	0050750	molecular_function	low-density lipoprotein particle receptor binding
R	0050830	biological_process	defense response to Gram-positive bacterium
S	0001849	molecular_function	complement component C1q complex binding
S	0005509	molecular_function	calcium ion binding
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005615	cellular_component	extracellular space
S	0006953	biological_process	acute-phase response
S	0006954	biological_process	inflammatory response
S	0008228	biological_process	opsonization
S	0010628	biological_process	positive regulation of gene expression
S	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
S	0010888	biological_process	negative regulation of lipid storage
S	0030169	molecular_function	low-density lipoprotein particle binding
S	0032677	biological_process	regulation of interleukin-8 production
S	0032930	biological_process	positive regulation of superoxide anion generation
S	0032945	biological_process	negative regulation of mononuclear cell proliferation
S	0033265	molecular_function	choline binding
S	0042310	biological_process	vasoconstriction
S	0042802	molecular_function	identical protein binding
S	0045087	biological_process	innate immune response
S	0046790	molecular_function	virion binding
S	0046872	molecular_function	metal ion binding
S	0050750	molecular_function	low-density lipoprotein particle receptor binding
S	0050830	biological_process	defense response to Gram-positive bacterium
T	0001849	molecular_function	complement component C1q complex binding
T	0005509	molecular_function	calcium ion binding
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005615	cellular_component	extracellular space
T	0006953	biological_process	acute-phase response
T	0006954	biological_process	inflammatory response
T	0008228	biological_process	opsonization
T	0010628	biological_process	positive regulation of gene expression
T	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
T	0010888	biological_process	negative regulation of lipid storage
T	0030169	molecular_function	low-density lipoprotein particle binding
T	0032677	biological_process	regulation of interleukin-8 production
T	0032930	biological_process	positive regulation of superoxide anion generation
T	0032945	biological_process	negative regulation of mononuclear cell proliferation
T	0033265	molecular_function	choline binding
T	0042310	biological_process	vasoconstriction
T	0042802	molecular_function	identical protein binding
T	0045087	biological_process	innate immune response
T	0046790	molecular_function	virion binding
T	0046872	molecular_function	metal ion binding
T	0050750	molecular_function	low-density lipoprotein particle receptor binding
T	0050830	biological_process	defense response to Gram-positive bacterium

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 5001

Chain	Residue
A	ASP60
A	ASN61
A	GLU138
A	GLN139
A	ASP140

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 5002

Chain	Residue
A	HOH288
A	GLU138
A	ASP140
A	GLU147
A	GLN150

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 6001

Chain	Residue
A	HIS38
A	HOH1742
A	HOH2754
A	HOH3098
T	HOH1822

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 5003

Chain	Residue
B	GLU138
B	ASP140
B	GLU147
B	GLN150
B	HOH208

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 5004

Chain	Residue
B	ASP60
B	ASN61
B	GLU138
B	GLN139
B	ASP140

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 5005

Chain	Residue
C	GLU138
C	ASP140
C	GLU147
C	GLN150
C	HOH1631
S	ASP70

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 5006

Chain	Residue
C	ASP60
C	ASN61
C	GLU138
C	GLN139
C	ASP140

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 5007

Chain	Residue
D	ASP60
D	ASN61
D	GLU138
D	GLN139
D	ASP140

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 5008

Chain	Residue
D	GLU138
D	ASP140
D	GLN150
D	HOH432
D	HOH2986

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 5009

Chain	Residue
E	ASP60
E	ASN61
E	GLU138
E	GLN139
E	ASP140
E	HOH367

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA E 5010

Chain	Residue
E	GLU138
E	ASP140
E	GLU147
E	GLN150
E	HOH399

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA F 5011

Chain	Residue
F	ASP60
P	ASP60
P	HOH393
P	HOH830

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA F 5012

Chain	Residue
F	GLU138
P	ASP140
P	HOH823

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA G 5013

Chain	Residue
G	ASP60
G	ASN61
G	GLU138
G	GLN139
G	ASP140

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 5014

Chain	Residue
G	GLU138
G	ASP140
G	GLU147
G	GLN150
G	HOH209
G	HOH2841

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 6002

Chain	Residue
G	HIS38
G	HOH3099
G	HOH3100
M	HOH2761

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA H 5015

Chain	Residue
H	ASP60
H	ASN61
H	GLU138
H	GLN139
H	ASP140
H	HOH2431

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA H 5016

Chain	Residue
H	GLU138
H	ASP140
H	GLU147
H	GLN150
H	HOH352

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA I 5017

Chain	Residue
I	ASP60
I	ASN61
I	GLU138
I	GLN139
I	ASP140

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA I 5018

Chain	Residue
I	GLU138
I	ASP140
I	GLU147
I	GLN150

---

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA J 5019

Chain	Residue
J	ASP140
J	HOH3097
M	ASP16

---

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA J 5020

Chain	Residue
J	ASP60
J	ASN61
J	GLU138
J	GLN139
J	ASP140

---

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA K 5021

Chain	Residue
K	ASP60
K	ASN61
K	GLU138
K	GLN139
K	ASP140
K	HOH1125
K	CA5022

---

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA K 5022

Chain	Residue
K	GLU138
K	ASP140
K	GLU147
K	GLN150
K	HOH1125
K	CA5021

---

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA L 5023

Chain	Residue
L	ASP60
L	ASN61
L	GLU138
L	GLN139
L	ASP140
L	HOH315

---

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA L 5024

Chain	Residue
L	GLU138
L	ASP140
L	GLU147
L	GLN150
L	HOH670

---

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN L 6003

Chain	Residue
H	HOH677
L	HIS38
L	PRO206
L	HOH2771
L	HOH2799
L	HOH3101

---

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA M 5025

Chain	Residue
M	ASP60
M	ASN61
M	GLU138
M	GLN139
M	ASP140

---

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA M 5026

Chain	Residue
J	HOH1069
M	GLU138
M	ASP140
M	GLU147
M	GLN150
M	HOH208

---

site_id	DC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA N 5027

Chain	Residue
N	ASP60
N	ASN61
N	GLU138
N	GLN139
N	ASP140
N	HOH416
N	CA5028

---

site_id	DC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA N 5028

Chain	Residue
N	GLU138
N	ASP140
N	GLU147
N	GLN150
N	HOH1568
N	CA5027

---

site_id	DC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA O 5029

Chain	Residue
O	ASP60
O	ASN61
O	GLU138
O	GLN139
O	ASP140
O	HOH214

---

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA O 5030

Chain	Residue
O	GLU138
O	ASP140
O	GLU147
O	GLN150
O	HOH299

---

site_id	DC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA P 5031

Chain	Residue
F	GLU147
P	ASP60
P	ASN61
P	GLU138
P	GLN139
P	ASP140
P	CA5032

---

site_id	DC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P 5032

Chain	Residue
F	GLU147
P	GLU138
P	ASP140
P	GLN150
P	HOH512
P	CA5031

---

site_id	DC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA Q 5033

Chain	Residue
Q	GLU138
Q	ASP140
Q	GLN150
Q	HOH3046

---

site_id	EC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA Q 5034

Chain	Residue
Q	ASP60
Q	ASN61
Q	GLU138
Q	GLN139
Q	ASP140
Q	HOH932

---

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA R 5035

Chain	Residue
R	ASP60
R	ASN61
R	GLU138
R	GLN139
R	ASP140

---

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA R 5036

Chain	Residue
R	GLU138
R	ASP140
R	GLU147
R	GLN150

---

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA S 5037

Chain	Residue
S	ASP60
S	ASN61
S	GLU138
S	GLN139
S	ASP140
S	HOH210

---

site_id	EC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA S 5038

Chain	Residue
S	GLU138
S	ASP140
S	GLU147
S	GLN150
S	HOH760

---

site_id	EC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN S 6004

Chain	Residue
B	HOH614
S	HIS38
S	HOH1430
S	HOH2486
S	HOH2692
S	HOH3050

---

site_id	EC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA T 5039

Chain	Residue
D	HOH210
T	GLU138
T	ASP140
T	GLU147
T	GLN150
T	HOH215

---

site_id	EC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA T 5040

Chain	Residue
D	HOH222
T	ASP60
T	ASN61
T	GLU138
T	GLN139
T	ASP140

---

site_id	EC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN T 6005

Chain	Residue
D	LYS69
D	ASP70
T	ASP60
T	HOH3102

---

Functional Information from PROSITE/UniProt

site_id	PS00289
Number of Residues	8
Details	PTX_1 Pentraxin domain signature. HiCtSWeS

Chain	Residue	Details
A	HIS95-SER102

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01172

Chain	Residue	Details
A	ASP60
A	ASN61
G	ASP140
G	GLN150
H	ASP60
H	ASN61
H	GLU138
H	GLN139
H	ASP140
H	GLN150
I	ASP60
I	ASN61
I	GLU138
I	GLN139
I	ASP140
I	GLN150
J	ASP60
J	ASN61
J	GLU138
J	GLN139
J	ASP140
J	GLN150
K	ASP60
K	ASN61
K	GLU138
K	GLN139
K	ASP140
K	GLN150
L	ASP60
L	ASN61
L	GLU138
L	GLN139
L	ASP140
L	GLN150
M	ASP60
M	ASN61
M	GLU138
M	GLN139
M	ASP140
M	GLN150
N	ASP60
N	ASN61
N	GLU138
N	GLN139
N	ASP140
N	GLN150
O	ASP60
O	ASN61
O	GLU138
O	GLN139
O	ASP140
O	GLN150
P	ASP60
P	ASN61
P	GLU138
P	GLN139
P	ASP140
P	GLN150
Q	ASP60
Q	ASN61
Q	GLU138
Q	GLN139
Q	ASP140
Q	GLN150
R	ASP60
R	ASN61
R	GLU138
R	GLN139
R	ASP140
R	GLN150
S	ASP60
S	ASN61
S	GLU138
S	GLN139
S	ASP140
S	GLN150
T	ASP60
T	ASN61
T	GLU138
T	GLN139
T	ASP140
T	GLN150
A	GLU138
A	GLN139
A	ASP140
A	GLN150
B	ASP60
B	ASN61
B	GLU138
B	GLN139
B	ASP140
B	GLN150
C	ASP60
C	ASN61
C	GLU138
C	GLN139
C	ASP140
C	GLN150
D	ASP60
D	ASN61
D	GLU138
D	GLN139
D	ASP140
D	GLN150
E	ASP60
E	ASN61
E	GLU138
E	GLN139
E	ASP140
E	GLN150
F	ASP60
F	ASN61
F	GLU138
F	GLN139
F	ASP140
F	GLN150
G	ASP60
G	ASN61
G	GLU138
G	GLN139

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:762075

Chain	Residue	Details
A	GLN1
B	GLN1
C	GLN1
D	GLN1
E	GLN1
F	GLN1
G	GLN1
H	GLN1
I	GLN1
J	GLN1
K	GLN1
L	GLN1
M	GLN1
N	GLN1
O	GLN1
P	GLN1
Q	GLN1
R	GLN1
S	GLN1
T	GLN1

---