3PSB
Furo[2,3-c]pyridine-based Indanone Oximes as Potent and Selective B-Raf Inhibitors
Summary for 3PSB
Entry DOI | 10.2210/pdb3psb/pdb |
Related | 3D4Q 3PSD |
Descriptor | B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE, ethyl 3-{[1-(hydroxyamino)-2H-inden-5-yl]amino}thieno[2,3-c]pyridine-2-carboxylate (2 entities in total) |
Functional Keywords | kinase, atp-binding, cardiomyopathy, disease mutation, metal-binding, nucleotide-binding, phorbol-ester binding, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, zinc-finger, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P15056 |
Total number of polymer chains | 2 |
Total formula weight | 71170.11 |
Authors | Morales, T.,Vigers, G.P.A.,Brandhuber, B.J. (deposition date: 2010-12-01, release date: 2011-01-19, Last modification date: 2023-09-06) |
Primary citation | Buckmelter, A.J.,Ren, L.,Laird, E.R.,Rast, B.,Miknis, G.,Wenglowsky, S.,Schlachter, S.,Welch, M.,Tarlton, E.,Grina, J.,Lyssikatos, J.,Brandhuber, B.J.,Morales, T.,Randolph, N.,Vigers, G.,Martinson, M.,Callejo, M. The Discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors. Bioorg.Med.Chem.Lett., 21:1248-1252, 2011 Cited by PubMed: 21211972DOI: 10.1016/j.bmcl.2010.12.039 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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