3PSB

Furo[2,3-c]pyridine-based Indanone Oximes as Potent and Selective B-Raf Inhibitors

Summary for 3PSB

• Entry DOI: 10.2210/pdb3psb/pdb
• Related: 3D4Q 3PSD
• Descriptor: B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE, ethyl 3-{[1-(hydroxyamino)-2H-inden-5-yl]amino}thieno[2,3-c]pyridine-2-carboxylate (2 entities in total)
• Functional Keywords: kinase, atp-binding, cardiomyopathy, disease mutation, metal-binding, nucleotide-binding, phorbol-ester binding, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, zinc-finger, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P15056
• Total number of polymer chains: 2
• Total formula weight: 71170.11

Authors

Morales, T.,Vigers, G.P.A.,Brandhuber, B.J. (deposition date: 2010-12-01, release date: 2011-01-19, Last modification date: 2023-09-06)

• Primary citation: Buckmelter, A.J.,Ren, L.,Laird, E.R.,Rast, B.,Miknis, G.,Wenglowsky, S.,Schlachter, S.,Welch, M.,Tarlton, E.,Grina, J.,Lyssikatos, J.,Brandhuber, B.J.,Morales, T.,Randolph, N.,Vigers, G.,Martinson, M.,Callejo, M.; The Discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors.; Bioorg.Med.Chem.Lett., 21:1248-1252, 2011; PubMed: 21211972; DOI: 10.1016/j.bmcl.2010.12.039

Experimental method

X-RAY DIFFRACTION (3.4 Å)