3PS2

Crystal structure of the Escherichia Coli LPXC/LPC-012 complex

Summary for 3PS2

Entry DOI	10.2210/pdb3ps2/pdb
Related	3PS1 3PS3
Descriptor	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, 4-[4-(3-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3R)-3-hydroxy-1-nitroso-1-oxobutan-2-yl]benzamide, ... (7 entities in total)
Functional Keywords	lpxc, hydrolase, deacetylation, antibiotic, acyl udp-glcnac, hydroxamate, lpc-012, baab sandwich, lipid a biosynthesis, lipid a synthesis, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological source	Escherichia coli IHE3034
Total number of polymer chains	1
Total formula weight	34777.97
Authors	Lee, C.-J.,Zhou, P. (deposition date: 2010-11-30, release date: 2011-01-19, Last modification date: 2024-02-21)
Primary citation	Liang, X.,Lee, C.J.,Chen, X.,Chung, H.S.,Zeng, D.,Raetz, C.R.,Li, Y.,Zhou, P.,Toone, E.J. Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. Bioorg.Med.Chem., 19:852-860, 2011 Cited by PubMed: 21194954 DOI: 10.1016/j.bmc.2010.12.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation