3PP7

Crystal structure of Leishmania mexicana pyruvate kinase in complex with the drug suramin, an inhibitor of glycolysis.

3PP7 の概要

• エントリーDOI: 10.2210/pdb3pp7/pdb
• 関連するPDBエントリー: 3IS4
• 分子名称: Pyruvate kinase, pyrene-1,3,6,8-tetrasulfonic acid, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: tim barrel, glycolysis, adp/atp binding, cytosol, symmetric drug, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Leishmania mexicana
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 110833.84

構造登録者

Morgan, H.P.,Auld, D.S.,McNae, I.W.,Nowicki, M.W.,Michels, P.A.M.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. (登録日: 2010-11-24, 公開日: 2010-12-15, 最終更新日: 2023-09-06)

• 主引用文献: Morgan, H.P.,McNae, I.W.,Nowicki, M.W.,Zhong, W.,Michels, P.A.,Auld, D.S.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D.; The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.; J.Biol.Chem., 286:31232-31240, 2011; PubMed: 21733839; DOI: 10.1074/jbc.M110.212613

実験手法

X-RAY DIFFRACTION (2.35 Å)